QT product

It is important to understand why a book on the QT interval, a lesser-known interval in electrocardiography, was written. Unfortunately, cardiac repolarization, as indicated by the QT interval, is a crucial target for anti-arrhythmic therapy, while also being a common side effect of numerous drugs. Dr. Woosley's group, Credible Meds, has played a significant role in cataloging the various compounds that can prolong the QT interval and potentially lead to arrhythmias. Research in basic cardiac electrophysiology has expanded our knowledge of cardiac repolarization and the crucial role that repolarization heterogeneity plays in arrhythmia development. Additionally, Dr. Antzelevitch and his colleagues have made significant contributions to our understanding of myocardial repolarization heterogeneity physiology.

For healthcare professionals treating patients with anti-arrhythmic drugs, understanding cardiac electrophysiology and pharmacology is essential. Similarly, for those involved in developing new cardiac anti-arrhythmic medications, knowledge of cardiac repolarization and current anti-arrhythmic therapy mechanisms is crucial. Given that many non-cardiac drugs can prolong the QT interval, individuals involved in drug development must also possess knowledge of cardiac electrophysiology, how to measure the QT interval, interpret T wave changes, and assess new drugs within existing regulatory frameworks.

"On the QT" aims to offer clinicians, medical students, drug developers, and regulators a foundational understanding of cardiac electrophysiology, anti-arrhythmic drug pharmacology, current regulatory standards, QT interval measurement, and other ECG manifestations related to cardiac repolarization. This book addresses a complex field and caters to individuals at varying levels of expertise, providing both basic knowledge and insights for experienced professionals. While this text covers a wide range of topics, it serves as a starting point to stimulate progress in the areas of QT interval and cardiac repolarization, which are in critical need of advancement after two decades without a comprehensive book on the subject.

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